Silver nanoparticles have attracted substantial interest within the biomedical domain due to their wide-ranging applications, encompassing antimicrobial, anticancer, and drug delivery modalities. Green synthesis approaches, which utilize biological entities such as algae, present an environmentally sound and economically viable alternative to conventional chemical synthesis methods. This review centers on the production of AgNPs via the marine alga Caulerpa chemnitzia, emphasizing its benefits as both a reducing and stabilizing agent. Caulerpa chemnitzia-synthesized AgNPs have demonstrated promising antimicrobial activity against a range of bacterial and fungal pathogens. In vitro studies have shown their cytotoxic effects on various cancer cell lines, indicating potential anticancer applications(González-Lamothe et al., 2009). The review summarizes these findings, emphasizing the mechanisms of action involved in the observed biological activities. This review aims to provide a comprehensive overview of the current state of research on Caulerpa chemnitzia-synthesized AgNPs(Dar et al., 2023). It covers the synthesis methods, characterization techniques, and biomedical applications of these nanoparticles. Furthermore, it addresses the challenges and future directions in the development of Caulerpa chemnitzia-synthesized AgNPs for clinical translation, including the need for optimization of green synthesis methods, surface modification, and thorough evaluation of biocompatibility and toxicity(Lalegani & Ebrahimi, 2020).