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I Research : Journal of Pharmacognosy

ISSN: XXXX-XXXX

The I Research : Journal of Pharmacognosy provides a resource content about the research activities carried out in the area of Pharmacognosy, Phytochemistry, Phytochemical analysis etc. This journal aims to publish all the recent research and reviews articles related to phytochemistry, standardization of phytochemicals, herbal formulation and their evaluation, Phyto chemical analysis, Isolation of active constituents from plant sources, plant tissue culture etc. It is the international journal of published Bi-Annual by I Research Academia . Authors should consult the latest instructions to authors before preparing their manuscripts. All contributions must be in English and should be submitted online only in a single word file.

Open AccessResearch Article
Peer Reviewed

FORMULATION AND EVALUATION OF HERBAL CAPSULES FROM MANGIFERA INDICA AND CENTELLA ASIATICA LEAVES EXTRACT WITH ANTI-OXIDANT ACTIVITY

ByS.SHARMATHI*,M.SWEATHA,N. THIRUKUMARAN,M. SURYA KUMAR ,R.SURYA
Keywords:
Mangifera indicaCentella asiaticapolyherbal capsuletotal phenolic contentDPPH assayantioxidant
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Abstract

Original research summary & clinical findings

Background: Oxidative stress arising from excessive reactive oxygen and nitrogen species is implicated in the pathogenesis of several chronic disorders, which has renewed interest in plant-derived antioxidants as safer alternatives to synthetic agents. Mangifera indica L. (mango) and Centella asiatica (L.) Urban (gotu kola) are two ethnomedicinally important species whose leaves are rich in phenolics, flavonoids and triterpenoids. Objective: This study was designed to extract, characterise and combine the hydroalcoholic leaf extracts of M. indica and C. asiatica into a single hard-gelatin capsule and to evaluate the resulting formulation for phytochemical composition, antioxidant potential and pharmaceutical quality. Methods: Shade-dried leaf powders were extracted separately by hydroalcoholic (70% ethanol-water) Soxhlet extraction. The extracts were screened qualitatively for phytoconstituents and quantitatively for total phenolic content (TPC, Folin-Ciocalteu method) and total flavonoid content (TFC, aluminium chloride method). A combined powder blend was evaluated for micromeritic properties, filled into hard gelatin capsules, and the capsules were assessed for physical appearance, weight variation, moisture content, disintegration time, content uniformity, in-vitro dissolution, FTIR drug-excipient compatibility and DPPH radical-scavenging activity.